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Hu ZL, Wen JF, Shen M, Liu Y. Expression of the macrophage antigen CD163 in rectal cancer cells is associated with early local recurrence and reduced survival time. [PubMed]105. 2007;110:91100. Eur J Cancer. J Natl Cancer Inst. Oncol Rep. Indeed, it was demonstrated that stimulation of TLR9 activates human plasmacytoid dendritic cells and B cells and this induces potent innate immune responses in preclinical tumor models as well as in patients[67]. It has also been suggested that increasing immune activity or immunotherapy will exacerbate the rate of immune escape and select for a tumor sub-population, which will be resistant to immunotherapy. 2009;61:177197. Toll-like receptor-3 as a target to enhance bioactivity of cancer immunotherapy. Tannock IF, de Wit R, Berry WR, Horti J, Pluzanska A, Chi KN, Oudard S, Thodore C, James ND, Turesson I, et al. [PMC free article] [PubMed]171. Ning H, Yang F, Jiang M, Hu L, Feng K, Zhang J, Yu Z, Li B, Xu C, Li Y, et al. Breast cancer expression of CD163, a macrophage scavenger receptor, is related to early distant recurrence and reduced patient survival. Jiang XX, Zhang Y, Liu B, Zhang SX, Wu Y, Yu XD, Mao N. 2000;248:171183. 2008;180:15981608. Cyclo-oxygenase-2 expression in esophageal adenocarcinoma as a determinant of clinical outcome following esophagectomy. Alici S, Ugras S, Bayram I, Izmirli M. J Intern Med. 55be9034d4
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released October 14, 2016